Richard is a middle-aged Englishman who runs a B&B in the fictional Val de Follet in the Loire Valley. Nothing ever happens to Richard, and really that's the way he likes it. One day, however, one of his older guests disappears, leaving behind a bloody handprint on the wallpaper. Another guest, the exotic Valerie, persuades a reluctant Richard to join her in investigating the disappearance. Richard remains a dazed passenger in the case until things become really serious and someone murders Ava Gardner, one of his beloved hens... and you don't mess with a fellow's hens! Unputdownable mystery set in rural France, by TV/radio regular and bestselling author Ian Moore - perfect for fans of Richard Osman's The Thursday Murder Club

Richard Ainsworth's French B&B has been taken over by a production company shooting a historical film at the Chateau de Valencay. But everything grinds to a halt with the sudden passing of an actor under suspicious circumstances. To get to the bottom of things, Valerie Dorcay and Richard offer catering services to the hastily resumed production. There they discover that the vanity, duplicity and murder of an 18th century French court is nothing compared to that of a 21st century film set, with more heads yet to roll.

Richard is a middle-aged Englishman who runs a B&B in the Val de Follet. Nothing ever happens to Richard, and really that's the way he likes it. Until scandal erupts in the nearby town of Saint-Sauver when its famous restaurant is downgraded from three 'Michelin' stars to two. The restaurant is shamed, the town is in shock and the leading goat's cheese supplier drowns himself in one of his own pasteurisation tanks. Or does he? Valerie d'Orcay, who is staying at the B&B while house-hunting in the area, isn't convinced that it's a suicide. Despite his misgivings, Richard is drawn into Valerie's investigation, and finds himself becoming a major player.

A KILLER. A SAINT. A TOWN FULL OF WHISPERS When an English expat is brutally murdered, his charred corpse left on a Loire Valley hillside, the police turn to juge d’instruction Matthieu Lombard to find the perpetrator. Instead, Lombard discovers a wealth of secrets, grudges and feuds in the idyllic town of Saint-Genèse-sur-Loire. He begins to suspect that the remaining members of the Comité des Fêtes know more about the death than they are letting on. But rather than towards an arrest, each clue he uncovers seems to point in one, unexpected direction: Joan of Arc. Is the answer to the murder hiding in the barroom gossip of the Lion d’Or? Or in another century altogether? The thrilling new crime series from The Times-bestselling author of Death and Croissants

A NEW CHRISTMAS STORY from the author of bestselling murder mystery Death & Croissants - the most hilarious murder mystery since Richard Osman's The Thursday Murder Club Richard Ainsworth is preparing for the Christmas of his dreams: quiet, no guests at his French B&B and his favourite films on the TV. None of which seems on the cards when his rural peace is shattered by the unexpected arrival of a familiar face. Valerie d'Orcay has hotfooted it from Paris with her chihuahua in tow and an invitation to a Christmas themed murder mystery game. Richard begrudgingly dresses up as Father Christmas, but the costume becomes the least of his worries when he realises this isn't a game to everyone. As other guests arrive to join the hunt, can Richard work out who is the victim - and who is murderer? READERS RALLY FOR FOLLET VALLEY! 'A very funny page-turner. Fantastique!' Adam Kay, This is Going to Hurt 'Bloody and funny. In fact, bloody funny!' Alan Carr 'A writer of immense wit and charm' Paul Sinha 'One of my favourite writers... hilarious and a great mystery too' Janey Godley 'Like going on a joyous romp through the Loire valley with Agatha Christie, PG Woodhouse and Mc Beaton. A delight' K. McDonnell 'Moore's French whodunnit is an engaging caper through the Loire Valley with an expat reluctant hero mixed up with a Maigret-like rural cast, a glamorous heroine and a couple of Mafia killers. It is finely paced, truly funny and written with a wry detachment that conjures up a gentler age of murder mystery' The Times

Richard is a middle-aged Englishman who runs a B&B in the Val de Follet. Nothing ever happens to Richard, and really that's the way he likes it. Until scandal erupts in the nearby town of Saint-Sauver when its famous restaurant is downgraded from three 'Michelin' stars to two. The restaurant is shamed, the town is in shock and the leading goat's cheese supplier drowns himself in one of his own pasteurisation tanks. Or does he? Valerie d'Orcay, who is staying at the B&B while house-hunting in the area, isn't convinced that it's a suicide. Despite his misgivings, Richard is drawn into Valerie's investigation, and finds himself becoming a major player.

Richard is a middle-aged Englishman who runs a B&B in the fictional Val de Follet in the Loire Valley. Nothing ever happens to Richard, and really that's the way he likes it. One day, however, one of his older guests disappears, leaving behind a bloody handprint on the wallpaper. Another guest, the exotic Valerie, persuades a reluctant Richard to join her in investigating the disappearance. Richard remains a dazed passenger in the case until things become really serious and someone murders Ava Gardner, one of his beloved hens... and you don't mess with a fellow's hens! Unputdownable mystery set in rural France, by TV/radio regular and bestselling author Ian Moore - perfect for fans of Richard Osman's The Thursday Murder Club

What would happen if you could make anything happen? When four ordinary British school kids have an encounter with a fallen angel from the stars one of them becomes as powerful as God. School time is over for everybody now, only there are still some questions to be answered. Who will be punished, who will be forgiven? What is worth saving, what will be erased? How do gods keep themselves from going insane with power, and why in Heaven and on Earth should they even try to?

Proteomics is the large-scale study of proteomes. A proteome is a set of proteins produced in an organism, system, or biological context. We may refer to, for instance, the proteome of a species (for example, Homo sapiens) or an organ (for example, the liver). The proteome is not constant; it differs from cell tofficell and changes over time. However, protein activity (often assessed by the reaction rate of the processes in which the protein is involved) is also modulated by many factors in addition to the expression level of the relevant gene. Several high-throughput technologies have been developed to investigate proteomes in depth. The most commonly applied are mass spectrometry (MS)-based techniques such as Tandem-MS and gel-based techniques such as differential in-gel electrophoresis (DIGE). These high-throughput technologies generate huge amounts of data. Databases are critical for recording and carefully storing this data, allowing the researcher to make connections between their results and existing knowledge. Proteomics is a rapidly growing field of molecular biology that is concerned with the systematic, high-throughput approach to protein expression analysis of a cell or an organism. Typical results of proteomics studies are inventories of the protein content of differentially expressed proteins across multiple conditions. Post-translational modifications, alternative splice products, and proteins intractable to classic separation techniques have presented a challenge towards the realization of the conventional definition of the word. Today, many different areas of study are explored by proteomics. Amongst them are protein-protein interaction studies, protein function, protein modifications, and protein localization studies. The fundamental goal of proteomics is not only to pinpoint all the proteins in a cell, but also to generate a complete three-dimensional map of the cell indicating their exact location. In many ways, proteomics runs parallel to genomics. The starting point for genomics is a gene in order to make inferences about its products (i.e. proteins), whereas proteomics begins with the functionally modified protein and works back to the gene responsible for its production. The techniques for proteome analysis are not as straightforward as those used in transcriptomics. However, the advantage of proteomics is that the real functional molecules of the cell are being studied. Strong gene expression, resulting in an abundant mRNA, does not necessarily mean that the corresponding protein is also abundant or indeed active in the cell. This Text is intended to give the molecular biologist a rudimentary understanding of the technologies behind proteomics and their application to address biological questions.

Biotechnology is technology that utilizes biological systems, living organisms or parts of this to develop or create different products. Biotechnology is a broad discipline in which biological processes, organisms, cells or cellular components are exploited to develop new technologies. New tools and products developed by biotechnologists are useful in research, agriculture, industry and the clinic. Modern biotechnology provides breakthrough products and technologies to combat debilitating and rare diseases, reduce our environmental footprint, feed the hungry, and use less and cleaner energy, and have safer, cleaner and more efficient industrial manufacturing processes.Brewing and baking bread are examples of processes that fall within the concept of biotechnology (use of yeast (= living organism) to produce the desired product). Such traditional processes usually utilize the living organisms in their natural form (or further developed by breeding), while the more modern form of biotechnology will generally involve a more advanced modification of the biological system or organism. With the development of genetic engineering in the 1970s, research in biotechnology (and other related areas such as medicine, biology etc.) developed rapidly because of the new possibility to make changes in the organisms' genetic material (DNA). Today, biotechnology covers many different disciplines (e.g. genetics, biochemistry, molecular biology, etc.). New technologies and products are developed every year within the areas of e.g. medicine, agriculture or industrial biotechnology (production of chemicals, paper, textiles and food.)